284 HLA-C*06:02 mediates an autoimmune response against melanocytes in psoriasis
نویسندگان
چکیده
منابع مشابه
is psoriasis an autoimmune disease?
psoriasis is a chronic, inflammatory and proliferative skin disease that has a wide distribution throughout the world. the immune system plays a critical role in developing this disease. in this survey, we have studied 50 patients suffering from psoriasis and 50 control subjects for various immunological factors, simultaneously. anti-stratum corneum (sc) antibody was evaluated by immunofluoresc...
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Psoriasis is a common inflammatory skin disease characterized by infiltration of inflammatory cells into the epidermis and altered keratin euclie differentiation psoriasis is the fourth most common skin disease in the United States about 2 in 100 people in America develop psoriasis of some stages of their life. It most commonly starts between the ages of 15 to 25. Possible factors and trigger c...
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Psoriasis vulgaris is a common T cell-mediated inflammatory skin disease with a suspected autoimmune pathogenesis. The human leukocyte antigen (HLA) class I allele, HLA-C*06:02, is the main psoriasis risk gene. Epidermal CD8(+) T cells are essential for psoriasis development. Functional implications of HLA-C*06:02 and mechanisms of lesional T cell activation in psoriasis, however, remained elus...
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Psoriasis is one of the most prevalent autoimmune skin diseases. However, its etiology and pathogenesis are still unclear. Over the last decade, omics-based technologies have been extensively utilized for biomarker discovery. As a result, some promising markers for psoriasis have been identified at the genome, transcriptome, proteome, and metabolome level. These discoveries have provided new in...
متن کاملHLA antigens in psoriasis and psoriatic arthritis.
HLA phenotypes were determined in 50 patients with psoriasis alone and in 50 patients with psoriasis and psoriatic arthritis. Positive associations were found in both groups with B13, B17, B37, Cw6, and DR7, and in addition with C4A6. Higher relative risks were found in respect to the patients with psoriasis alone compared with those with arthritis, and this suggests the involvement of addition...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2016
ISSN: 0022-202X
DOI: 10.1016/j.jid.2016.06.304